Endocrine Abstracts

Type 2 diabetes (T2D) affects 1 in 15 people in the U.K, ischaemic damage is predominant and caused by hypoxia. The physiological response to hypoxia is an increase in the transcription factor hypoxia inducible factor (HIF)-1α, which results in reduced oxygen consuming. Previously we have demonstrated that the diabetic heart fails to respond to hypoxia and the aim of this work was to determine if a similar effect was seen in the kidney. HEK293T cells were incubated for 8h...